Group A serum mixes with Group A erythrocytes
Group A serum mixes with group B erythrocytes
Group AB serum mixes with Group O erythrocytes
Group B serum mixes with Group B erythrocytes
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Agglutination (clumping of red blood cells) occurs when antibodies in the serum react with matching antigens on erythrocytes (RBCs).
Blood Group Antigens and Antibodies
Blood Group
Antigen on RBC
Antibody in Serum
A
A antigen
Anti-B
B
B antigen
Anti-A
AB
A and B
None
O
None
Anti-A and Anti-B
Check the Options
A. Group A serum + Group A erythrocytes
Group A serum has anti-B
Group A erythrocytes have A antigen
No reaction → No agglutination
B. Group A serum + Group B erythrocytes
Group A serum has anti-B
Group B erythrocytes have B antigen
Anti-B reacts with B antigen → Agglutination occurs ✅
C. Group AB serum + Group O erythrocytes
AB serum has no antibodies
O erythrocytes have no antigens
No agglutination
D. Group B serum + Group B erythrocytes
Group B serum has anti-A
Group B erythrocytes have B antigen
No agglutination
✅ Correct Answer: B — Group A serum mixes with Group B erythrocytes.



