Key Features:

- No of Pages: 36

- No of Chapters: 5

- Tables Included

- Pie-Charts Included

- Graphs Included

- Questionnaire Included

- References Included

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Introduction:

Abstract

ABSTRACT

This research study was conducted to find out about the knowledge, attitude and practice of sickle cell crises prevention among diagnosed patients attending Lagos University Teaching Hospital, (LUTH), Idi Araba, Lagos. Sickle cell disease is a hereditary problem that causes abnormal type of haemoglobin (Hb-s) in the red blood cell. The pains that occurs suddenly and last several hours to several days as a result of blockage of small blood vessels that carries blood to the bone is known as sickle cell crises. The knowledge, attitude and practice of sickle cell crises prevention is the researcher’s stated problem of study, and a structured questionnaire was given to the patients, same retrieved. The data obtained were analyzed and interpreted based on the findings using percentage, tables, charts and figures. Based on the findings, recommendations were made. The study revealed that ninety six percent (96%) of the respondents agreed that sickle cell disease is a hereditary problem inherited from both parent but not communicable, while four (4%) disagreed. It further revealed that fifty five percent (55%) of the respondents agreed that sickle cell disease has no cure, while forty five (45%) disagreed. Also, ninety five percent (95%) agreed that everyone should know their genotype status, while five percent (5%) disagreed. Eighty nine percent (89%) agreed that there is stigmatization and discrimination against sickle cell disease patients, while eleven percent (11%) disagreed. The study further revealed that, one hundred percent (100%) agreed that daily intake of folic acid; vitamin B12 and B6 supplements are recommended routine drugs for sickle cell patients. At the same time, ninety one percent (91%) of the respondents agree that travelling to places, weather and strainous activities triggers sickle cell disease crisis. Recommendations were made based on the findings, that strictly adherence to drug regimen, increase fluid intake as well as avoidance of strainous activities will prevent sickling crises.

Table of Content

TABLE OF CONTENTS

CONTENT PAGE

Cover Page i

Title Page ii

Declaration iii

Certification iv

Dedication v

Acknowledgement vi

Table of Content vii-ix

List of Table x

List of Figure xi

Abstract xii-xiii

CHAPTER ONE

Introduction 1

1.0 Background of the study 1-2

1.1 Statement of the problem 2-3

1.2 Objectives of the study 3

1.3 Significance of the study 3

1.4 Scope of the study and limitation 4

1.5 Operational definition of terms 4

1.6 Research Questions 5

1.7 Research Hypothesis

CHAPTER TWO

2.0 Literature review 6-8

2.1 Inheritance pattern of sickle cell disease 9-11

2.2 Incidence of sickle cell disease 11-12

2.3 Attitude of patients 12-13

2.4 Types of sickle cell disease 13

2.5 Types of sickle cell crises 13-15

2.6 Symptoms 15-16

2.7 Prevention of sickle cell crises 16-19

2.8 Complications 19-21



CHAPTER THREE

RESEARCH METHODOLOGY 22

3.0 Research design 22

3.1 Study area 22

3.2 Population of the study 22

3.3 Sampling technique and Sample size 22

3.4 Development of a research instrument 23

3.5 Validity 23

3.6 Reliability of the instrument 23

3.7 Data collection 23

3.8 Data analysis 23



CHAPTER FOUR

Result Analysis and Findings 24-49

4.0 Presentation of tables, charts, figures and interpretation 24-49

4.1 Discussion of findings 50



CHAPTER FIVE

Summary, Conclusion and Recommendations 51-53

5.0 Summary 51

5.1 Conclusion 51

5.2 Recommendations 52-53

Questionnaire 54-57

References 58-60

Introduction

1.0 BACKGROUND OF THE STUDY.

Sickle cell disease is an inherited disease of the red blood cell in which there is an abnormal type of haemoglobin (HB-S). The globin chain structure is changed by the substitutions of one amino acid and this effectively changes the behavior of the whole molecule. Sickle cell disease occurs almost exclusively among black Americans and black Africans. Sickle cell trait is a heterozygous state; the individual has inherited the Hb-S gene from only one parent. Only a small amount of the individual’s haemoglobin is type Hb-S. The person with sickle cell trait is usually asymptomatic and is often unaware of the condition which is only reliably detected by haemoglobin electrophoresis.

In sickle cell disease, certain red blood cell becomes crescent-shaped (Ogamdi, 1994).

These abnormal haemoglobin known as haemoglobin S, are fragile. A person who has sickle cell can become more likely to infection because the damaged cells eventually clog the spleen.

Sickle cell crises is a pain that can begin suddenly and last several hours to several days. It happens when sickled red blood cells block small vessels that transport blood during blood circulation. The pain can be throbbing, sharp, dull or stabbing.

The knowledge, attitude and practice of sickle cell crises prevention has been identified and acknowledged as a strategy for prevention of sickling crisis.

This research work has explored into the knowledge, attitude and practice of sickle cell crises prevention among diagnosed patients attending LUTH. It has further discussed the concept of sickle cell disease, inheritance pattern of sickle cell disease, incidence of sickle cell disease, attitude of patients, types of sickle cell disease, type of sickle cell crises, symptoms, complications as well as prevention of sickle cell crises.